Reaktion #1470043

Reaktionsgleichung

7-phenylbenzo[b]thiophene-5-carboxylic acid

N-methylethylamine

cyclohexane ethanol ethyl acetate

triethylamine

→

N-ethyl-N-methyl-7-phenylbenzo[b]thiophene-5-carboxamide

Lösungsmittel

toluene

thionyl chloride

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationAfter filtering
2. 2
   Sonstigedrying

Vorschrift

The reaction is carried out as in Example 1, starting with 7-phenylbenzo[b]thiophene-5-carboxylic acid (3 g) in toluene (30 cc) and thionyl chloride (2.64 cc) and then triethylamine (5 cc) and N-methylethylamine (1.01 cc) in toluene (30 cc). After chromatography of the residue on silica gel using a cyclohexane:ethanol:ethyl acetate (90:5:5 by volume) mixture as the eluent, a residue is obtained, which is stirred overnight in 40°-60° petroleum spirit (50 cc). After filtering and drying, N-ethyl-N-methyl-7-phenylbenzo[b]thiophene-5-carboxamide (1.5 g), m.p. 93° C., is isolated.

Quelle