Reaktion #1470037

Reaktionsgleichung

7-phenylbenzo[b]thiophene-5-carboxylic acid

2-butanamine

cyclohexane ethyl acetate

triethylamine

→

N-(1-methylpropyl)-7-phenylbenzo[b]thiophene-5-carboxamide

Lösungsmittel

toluene

thionyl chloride

toluene

Reaktionsbedingungen

Vorschrift

the reaction is carried out as in Example 1, starting with 7-phenylbenzo[b]thiophene-5-carboxylic acid (3 g) in toluene (30 cc) and thionyl chloride (2.6 cc) and then adding triethylamine (9.94 cc) and 2-butanamine (1.2 cc) in toluene (30 cc). After chromatography of the residue on silica gel using a cyclohexane:ethyl acetate (50:50 by volume) mixture as the eluent, N-(1-methylpropyl)-7-phenylbenzo[b]thiophene-5-carboxamide (2.35 g), m.p. 195° C., is obtained.

Quelle