Reaktion #1463486

Reaktionsgleichung

cyclohexane

4-(4-propylcyclohexyl)cyclohexane

acetone

water

→

3-(4-(4-propylcyclohexyl)cyclohexyl)-2E-propenal

Lösungsmittel

hydrochloric acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturby heating the solution
2. 2
   Temperaturunder reflux for 4 hours
3. 3
   Extraktionextracting with ether (50 ml)
4. 4
   Trocknendrying the organic layer over anhydrous magnesium sulfate
5. 5
   Einengenconcentrating under reduced pressure

Vorschrift

The resulting cyclohexane derivative was dissolved in a mixed solvent of acetone (80 ml) with 2N hydrochloric acid (8 ml), followed by heating the solution under reflux for 4 hours, cooling the reaction mixture down to room temperature after completion of the stirring, adding water, extracting with ether (50 ml), drying the organic layer over anhydrous magnesium sulfate, and concentrating under reduced pressure to obtain 3-(4-(4-propylcyclohexyl)cyclohexyl)-2E-propenal (3.1 g, 12 mmols). This product was used in the subsequent reaction without any purification.

Quelle