Reaktion #1462374

ord-584039e801454c479c6577ce1f234983

Reaktionsgleichung

CC(C)[C@](C)(N)C(=O)O
L-α-methyl-valine
CC[C@@H](C)[C@H](N)C(=O)O
L-allo-isoleucine
O=S(=O)(Cl)c1ccc(Br)cc1
4-bromobenzenesulfonyl chloride
O=S(=O)(Cl)c1ccc(Cl)cc1
4-chlorobenzenesulfonyl chloride
CC(c1ccccc1)C(N)C(=O)O
β-methyl-DL-phenylalanine
CC[C@@H](C)[C@@H](N)C(=O)O
D-isoleucine
→
CC[C@@H](C)[C@H](CO)NS(=O)(=O)c1ccc(Br)cc1
4-Bromo-N-[(1R,2R)-1-(hydroxymethyl)-2-methylbutyl]benzenesulfonamide

Edukte

CC(C)[C@](C)(N)C(=O)O
L-α-methyl-valine
CC[C@@H](C)[C@H](N)C(=O)O
L-allo-isoleucine
O=S(=O)(Cl)c1ccc(Br)cc1
4-bromobenzenesulfonyl chloride
O=S(=O)(Cl)c1ccc(Cl)cc1
4-chlorobenzenesulfonyl chloride
CC(c1ccccc1)C(N)C(=O)O
β-methyl-DL-phenylalanine
CC[C@@H](C)[C@@H](N)C(=O)O
D-isoleucine

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeThe following compounds (Examples 33–39, Table 5) were prepared

Vorschrift

The following compounds (Examples 33–39, Table 5) were prepared using 4-bromobenzenesulfonyl chloride, and 4-chlorobenzenesulfonyl chloride, with D-isoleucine, L-α-methyl-valine, β-methyl-DL-phenylalanine, and L-allo-isoleucine and following the procedure outlined in Example 33. This procedure is outlined in the following Scheme.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07166622B2uspto-grants-2007_01