Reaktion #1462
ord-fd88e66de55049f7ad9914c5bfbadd5a
Reaktionsgleichung
ethyl4-(4-bromophenyl)butanoate
Compound C
ethyl4-(4-bromophenyl)butanoate
ethyl (3-bromophenyl)acetate
ethyl 3-bromophenylacetate
Compound B
ethyl 3-bromophenylacetate
→
title compound
Ethyl 4-(3-bromophenyl)butanoate
Edukte
Reagenzien
Keine
Reaktionsbedingungen
Detaillierte Bedingungen
See reaction.notes.procedure_details.
Vorschrift
Employing the same general multistep preparation as for ethyl4-(4-bromophenyl)butanoate (Compound C), 60 g (246 mmol) of ethyl (3-bromophenyl)acetate (Compound B) was converted into the title compound (oil) using 255 ml (255 mmol) of diisobutylaluminum hydride (DIBAL-H, 1M in hexane), 85.8 g (250 mmol) of (carbethoxymethylene)triphenylphosphorane and 1.7 g of 10% Pd/C.