Reaktion #1459905

Reaktionsgleichung

Ethyl (5-chloro-2-fluoro-4-((1-isoquinolinylcarbonyl)amino)phenyl)acetate

NaOH

HCl

→

(5-chloro-2-fluoro-4-((1-isoquinolinylcarbonyl)amino)phenyl)acetic acid

Ausbeute 91.3%

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe crystals thus precipitated
2. 2
   Filtrationwere collected by filtration under reduced pressure
3. 3
   Waschenwashed with water
4. 4
   Sonstigedried under reduced pressure

Vorschrift

Ethyl (5-chloro-2-fluoro-4-((1-isoquinolinylcarbonyl)amino)phenyl)acetate (690 mg, 1.78 mmol) was dissolved in THF (18 ml). To the resulting solution was added 0.25N NaOH (10.7 ml, 2.68 mmol), and the resulting mixture was stirred at room temperature for 7 hours. The reaction mixture was poured into 1N HCl (3.0 ml). The crystals thus precipitated were collected by filtration under reduced pressure, washed with water, and dried under reduced pressure to give (5-chloro-2-fluoro-4-((1-isoquinolinylcarbonyl)amino)phenyl)acetic acid (583 mg, 91%) as a pale yellow solid.

Quelle