Reaktion #1455842

Reaktionsgleichung

ammonium chloride

2-{[5-amino-4-(1,3-benzodioxol-5-yl)-1-methyl-1H-pyrazol-3-yl]oxy}ethyl acetate

sodium

→

title compound

Ausbeute 97.9%

2-{[5-amino-4-(1,3-benzodioxol-5-yl)-1-methyl-1H-pyrazol-3-yl]oxy}-1-ethanol

Ausbeute 97.9%

Lösungsmittel

water

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   ExtraktionThe mixture was extracted with ethyl acetate (3×6 ml)
2. 2
   TrocknenThe organic fraction was dried over sodium sulfate
3. 3
   Einengenconcentrated under reduced pressure

Vorschrift

To a solution of 2-{[5-amino-4-(1,3-benzodioxol-5-yl)-1-methyl-1H-pyrazol-3-yl]oxy}ethyl acetate (100 mg) (Preparation 33) in ethanol (6 ml) at room temperature, was added sodium hydroxyde (10 mg). After one hour, the reaction was diluted with water (5 ml ) and an aqueous saturated solution of ammonium chloride (10 ml ). The mixture was extracted with ethyl acetate (3×6 ml). The organic fraction was dried over sodium sulfate and concentrated under reduced pressure to yield the title compound as a white solid (85 mg).

Quelle