Reaktion #1454946

Reaktionsgleichung

1,10-Decanediol

hydrobromic acid

→

10-bromodecan-1-ol

Ausbeute 89.0%

Lösungsmittel

cyclohexane

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe reaction mixture was refluxed for six hours
2. 2
   SonstigeAfter the reaction
3. 3
   Extraktionthe mixture was extracted three times with diethyl ether
4. 4
   Waschenwashed with saline solution
5. 5
   Trocknendried over magnesium sulfate
6. 6
   Filtrationfiltered
7. 7
   workup.DISTILLATIONthe solvent was distilled off under reduced pressure
8. 8
   SonstigePurification of the residue by silica gel flash chromatography (hexane:ethyl acetate=7:3)

Vorschrift

1,10-Decanediol (4 g) was dissolved in 100 ml of cyclohexane, and 57% aqueous hydrobromic acid solution (58 ml) was added to this solution. The reaction mixture was refluxed for six hours while stirring. After the reaction, the mixture was extracted three times with diethyl ether. The organic layer was neutralized with saturated sodium hydrogen carbonate solution, washed with saline solution, dried over magnesium sulfate, and filtered, and the solvent was distilled off under reduced pressure. Purification of the residue by silica gel flash chromatography (hexane:ethyl acetate=7:3) gave 10-bromodecan-1-ol as white crystals at an 89% yield.

Quelle