Reaktion #1451701

Reaktionsgleichung

2-bromo-4,6-diaminonicotinonitrile

2-propanol

sodium

sodium

→

pale yellow crystals

Ausbeute 53.0%

4,6-Diamino-2-isopropoxy-nicotinonitrile

Ausbeute 53.0%

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturA heavy walled, sealable tube suitable for microwave heating
2. 2
   Sonstigehad reacted (15 minutes)
3. 3
   SonstigeThe tube was sealed
4. 4
   Temperaturthen cooled
5. 5
   SonstigeThe precipitate was collected
6. 6
   Waschenwashed with water until pH=7
7. 7
   Sonstigedried under reduced pressure at 95° C.

Vorschrift

A heavy walled, sealable tube suitable for microwave heating was charged with 6 mL of 2-propanol and 150 mg (6.5 mmol) of sodium. The mixture was stirred at 95° C. until all of the sodium had reacted (15 minutes), then 650 mg (3.05 mmol) of 2-bromo-4,6-diaminonicotinonitrile was added. The tube was sealed, and the mixture was heated with a microwave apparatus at 150° C. for 10 minutes then cooled and diluted with 30 mL of water. The precipitate was collected, washed with water until pH=7, then dried under reduced pressure at 95° C. to provide 312 mg (53%) of pale yellow crystals.

Quelle