Reaktion #1448775

Reaktionsgleichung

NaH

2-Pyrrolidin-1-yl-ethanol

1-Fluoro-2-nitro-4-trifluoromethyl-benzene

→

title compound

1-[2-(2-Nitro-4-trifluoromethyl-phenoxy)-ethyl]-pyrrolidine

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeBubbling
2. 2
   workup.ADDITIONwas added
3. 3
   Sonstigecompletion of the reaction
4. 4
   SonstigeThe reaction was quenched by addition of H2O
5. 5
   Extraktionthe mixture was extracted with EtOAc
6. 6
   Trocknendried with MgSO4
7. 7
   Filtrationfiltered
8. 8
   Einengenconcentrated

Vorschrift

To a suspension of NaH (60%, 248 mg, 6.21 mmol) in dry THF was added 2-Pyrrolidin-1-yl-ethanol (0.68 mL, 5.74 mmol). Bubbling was observed. The reaction was stirred for 5 minutes, at which time 1-Fluoro-2-nitro-4-trifluoromethyl-benzene (0.67 mL, 4.79 mmol) was added. The solution turned red, and LCMS indicated completion of the reaction. The reaction was quenched by addition of H2O, and the mixture was extracted with EtOAc, dried with MgSO4, filtered, and concentrated to afford the title compound as an orange oil.

Quelle