Reaktion #1447133

Reaktionsgleichung

dimethylamine

2-bromo-1-(4-bromophenyl)ethanone

→

title compound

Ausbeute 86.0%

1-(4-Bromophenyl)-2-(dimethylamino)ethanone

Ausbeute 86.0%

Lösungsmittel

methanol

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe solvent was removed by distillation
2. 2
   Sonstigethe residue was then purified by column chromatography on silica gel (hexane:ethyl acetate=10:1 to 0:100)

Vorschrift

A 2.0 M solution of dimethylamine (0.5 mmol) in methanol was added to a solution of 2-bromo-1-(4-bromophenyl)ethanone (114.5 mg, 0.41 mmol) in tetrahydrofuran (2 ml), and the mixture was stirred at room temperature for 15 min. The solvent was removed by distillation, and the residue was then purified by column chromatography on silica gel (hexane:ethyl acetate=10:1 to 0:100) to give 84.7 mg (yield 86%) of the title compound.

Quelle