Reaktion #1447123

Reaktionsgleichung

1-(2-aminophenyl)-3-methylbutan-1-one

hydrazine hydrate

water

potassium hydroxide

→

[2-(3-methylbutyl)-phenyl]amine

Ausbeute 72.1%

Lösungsmittel

ethyl acetate

triethylene glycol

Reaktionsbedingungen

Aufarbeitung

1. 1
   WaschenThe organic phase is again washed with water
2. 2
   Trocknendried over magnesium sulphate
3. 3
   Einengenconcentrated under reduced pressure
4. 4
   SonstigePurification by column chromatography (cyclohexane/ethyl acetate 3:1)

Vorschrift

A solution comprising 8.0 g (0.045 mol) of 1-(2-aminophenyl)-3-methylbutan-1-one (X-1), 6.8 g (0.135 mol) of hydrazine hydrate and 7.6 g (0.135 mol) of potassium hydroxide in 90 ml of triethylene glycol is heated at 210° C. for 6 h. For work-up, water and ethyl acetate are added at room temperature. The organic phase is again washed with water, dried over magnesium sulphate and concentrated under reduced pressure. Purification by column chromatography (cyclohexane/ethyl acetate 3:1) gives 5.3 g (71.5% of theory) of [2-(3-methylbutyl)-phenyl]amine.

Quelle