Reaktion #1447115

ord-7863db74bba348a29996a1e43f4b2acd

Reaktionsgleichung

Cc1cc(OP(=O)(Cl)Cl)c(C(C)C)cc1Cl
4-chloro-2-isopropyl-5-methylphenyl dichlorophosphate
CCOC(=O)[C@H](C)N.Cl
L-alanine ethyl ester hydrochloride
CCN(CC)CC
Et3N
→
CCOC(=O)[C@H](C)NP(=O)(Cl)Oc1cc(C)c(Cl)cc1C(C)C
title compound
CCOC(=O)[C@H](C)NP(=O)(Cl)Oc1cc(C)c(Cl)cc1C(C)C
Ethyl N-[chloro(4-chloro-2-isopropyl-5-methylphenoxy)phosphoryl]-L-alaninate

Edukte

Cc1cc(OP(=O)(Cl)Cl)c(C(C)C)cc1Cl
4-chloro-2-isopropyl-5-methylphenyl dichlorophosphate
CCOC(=O)[C@H](C)N.Cl
L-alanine ethyl ester hydrochloride
CCN(CC)CC
Et3N

Reagenzien

Keine

Lösungsmittel

ClCCl
DCM

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Following the procedure described for Example 1, step 2, treatment of a solution in DCM (0.098 M) of 4-chloro-2-isopropyl-5-methylphenyl dichlorophosphate with L-alanine ethyl ester hydrochloride (1.0 eq.) and Et3N (2.0 eq.) provided the title compound as a colorless oil as a 1:1.35* mixture of diastereoisomers. 31P NMR (300 MHz, CD3OD): δ 8.5 and 8.8*.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07879815B2uspto-grants-2011_02