Reaktion #1447102

Reaktionsgleichung

KOtBu

1-Bromo-4-cyano-3-fluoro-5-(4-ethyl-phenyl)-benzene

KOtBu

HCl

cyclobutanol

→

title compound

1-Bromo-4-cyano-3-cyclobutoxy-5-(4-ethyl-phenyl)-benzene

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONcharged with a stir bar
2. 2
   workup.ADDITIONis added
3. 3
   ExtraktionThe resulting mixture is extracted with ethyl acetate
4. 4
   Trocknenthe combined organic phases are dried (sodium sulphate)
5. 5
   Sonstigethe solvent is removed

Vorschrift

1-Bromo-4-cyano-3-fluoro-5-(4-ethyl-phenyl)-benzene (1.2 g) is added to a flask charged with a stir bar, KOtBu (0.5 g) and cyclobutanol (3.0 g). The solution is stirred at room temperature overnight, before another portion of KOtBu (0.2 g) is added. The solution is stirred for another 5 h and then neutralized with 1 M aqueous HCl solution. The resulting mixture is extracted with ethyl acetate, the combined organic phases are dried (sodium sulphate) and the solvent is removed to give the title compound.

Quelle