Reaktion #1447098

Reaktionsgleichung

hydrochloric acid

N-[4-bromo-2-(4-ethyl-benzyl)-5-methoxy-phenyl]-acetamide

→

title compound

4-Bromo-2-(4-ethyl-benzyl)-5-methoxy-phenylamine

Lösungsmittel

isopropanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe solution is heated
2. 2
   Temperaturat reflux temperature for 8 h
3. 3
   Einengenconcentrated under reduced pressure
4. 4
   Sonstigeto remove most of the alcohol
5. 5
   workup.ADDITIONAqueous NaHCO3 solution is added to the rest
6. 6
   Extraktionthe resulting mixture is extracted twice with ethyl acetate
7. 7
   WaschenThe combined organic extracts are washed with brine
8. 8
   Trocknendried (Na2SO4)
9. 9
   Einengenconcentrated

Vorschrift

Half-concentrated hydrochloric acid (5 mL) is added to a solution of N-[4-bromo-2-(4-ethyl-benzyl)-5-methoxy-phenyl]-acetamide (2.8 g) in isopropanol (20 mL). The solution is heated at reflux temperature for 8 h and then concentrated under reduced pressure to remove most of the alcohol. Aqueous NaHCO3 solution is added to the rest and the resulting mixture is extracted twice with ethyl acetate. The combined organic extracts are washed with brine, dried (Na2SO4) and concentrated to give the title compound.

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