Reaktion #1447093

Reaktionsgleichung

water

Sodium methoxide

(2-bromo-4-fluoro-phenyl)-(4-ethyl-phenyl)-methanone

sodium methoxide

→

(2-Bromo-4-methoxy-phenyl)-(4-ethyl-phenyl)-methanone

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONis added
2. 2
   Extraktionthe resulting mixture is extracted with ethyl acetate
3. 3
   TrocknenThe organic phase is dried (sodium sulphate)
4. 4
   Sonstigethe solvent is removed
5. 5
   Sonstigethe residue is chromatographed on silica gel (cyclohexane/ethyl acetate 20:1->9:1)

Vorschrift

Sodium methoxide (10.5 g) is added portionwise to (2-bromo-4-fluoro-phenyl)-(4-ethyl-phenyl)-methanone (43.0 g) dissolved in DMF (200 mL). The solution is stirred overnight, before another portion of sodium methoxide (5.5 g) is added. After another 3 h of stirring, water is added and the resulting mixture is extracted with ethyl acetate. The organic phase is dried (sodium sulphate), the solvent is removed and the residue is chromatographed on silica gel (cyclohexane/ethyl acetate 20:1->9:1).

Quelle