Reaktion #1444665

Reaktionsgleichung

9-[4-(piperazin-1-yl)phenyl]aminoacridine

Acridin-9-yl-[4-(piperazine-1-yl)phenyl]amine

acetyl chloride

pyridine

triethylamine

→

title compound

Ausbeute 1.0%

Acridin-9-yl-[4-(4-acetylpiperazine-1-yl)phenyl]amine

Ausbeute 1.0%

Lösungsmittel

chloroform

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe solvents were removed under vacuum
2. 2
   Sonstigethe residue was purified by silica gel chromatography (eluent chloroform: methanol 6:1)
3. 3
   Sonstigeevaporated
4. 4
   Extraktionextracted with chloroform
5. 5
   TrocknenAfter drying over sodium sulfate
6. 6
   Sonstigethe organic layer was evaporated

Vorschrift

35 mg (0.10 mmol) of 9-[4-(piperazin-1-yl)phenyl]aminoacridine (Example 16) was dissolved in 2 ml of chloroform, 7.1 μl (0.10 mmol) of acetyl chloride and catalytical amounts of pyridine and triethylamine were added. After 2 h of stirring at room temperature, the solvents were removed under vacuum, and the residue was purified by silica gel chromatography (eluent chloroform: methanol 6:1). The fractions with the title compound were combined, evaporated, taken up to water and extracted with chloroform. After drying over sodium sulfate, the organic layer was evaporated to obtain the title compound (6%, overall yield 1%).

Quelle