Reaktion #1442874

Reaktionsgleichung

4-chlorobenzoylacetonitrile

methyl iodide

guanidine nitrate

DMSO

sodium hydride

→

2-Amino-4-(p-chlorophenyl)-6-(methylthio)-pyrimidine-5-carbonitrile

Lösungsmittel

carbon disulphide

triethylamine

DMF

Reaktionsbedingungen

Vorschrift

From 4-chlorobenzoylacetonitrile with sodium hydride, carbon disulphide and methyl iodide in DMSO. Then treatment with guanidine nitrate and triethylamine in DMF. EI-MS m/e (%): 278 (M{37Cl}+, 14), 277 ([M{37Cl}—H]+, 42), 276 (M{35Cl} +, 46), 275 ([M{35Cl}—H]+, 100), 241 ([M—Cl]+, 30).

Quelle