Reaktion #1442859

Reaktionsgleichung

4-(7-methyl-1-naphthalen-1-ylmethyl-2-oxo-2,3-dihydro-1H-indol-6-yl)-benzonitrile

1-trityl-1H-pyrazole-4-carbaldehyde

pyrrolidine

→

13B

Ausbeute 63.2%

4-[7-Methyl-1-naphthalen-1-ylmethyl-2-oxo-3-(1-trityl-1H-pyrazol-4-ylmethylene)-2,3-dihydro-1H-indol-6-yl]-benzonitrile

Ausbeute 63.2%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturAfter cooled to room temperature
2. 2
   Sonstigethe reaction mixture formed a precipitate
3. 3
   SonstigeThe solid was collected
4. 4
   Waschenwashed with cold methanol

Vorschrift

To a suspension of 4-(7-methyl-1-naphthalen-1-ylmethyl-2-oxo-2,3-dihydro-1H-indol-6-yl)-benzonitrile (300 mg, 0.773 mmol) and 1-trityl-1H-pyrazole-4-carbaldehyde (303 mg, 0.928 mmol) in methanol (5 ml) was added pyrrolidine (0.323 ml, 3.87 mmol). The reaction mixture was heated at 70° C. overnight. After cooled to room temperature, the reaction mixture formed a precipitate. The solid was collected and washed with cold methanol to give the title compound of 13B as a bright yellow solid (340 mg, 63.2% yield).

Quelle