Reaktion #1442485

ord-b5f58b4a9ac14795aaca94379e302bf9

Reaktionsgleichung

OB(O)O
Boric acid
OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)CO
sorbitol
NC(=O)c1ccccc1O
salicylamide
→
NC(=O)c1ccccc1O.OB(O)O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)CO
salicylamide sorbitol borate
Ausbeute 86.6%

Edukte

OB(O)O
Boric acid
OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)CO
sorbitol
NC(=O)c1ccccc1O
salicylamide

Reagenzien

Keine

Lösungsmittel

Cc1ccccc1
toluene

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeSalicylamide/sorbitol borate was prepared
  2. 2
    Sonstigethe byproduct water (˜9 grams) was continuously removed from the reaction by azeotropic distillation
  3. 3
    SonstigeThe final solution was evaporated
  4. 4
    Sonstigeto remove toluene under vacuum

Vorschrift

Salicylamide/sorbitol borate was prepared as follows. Boric acid (10.3 grams), sorbitol (30.4 grams), and salicylamide (22.9 grams) were added to a 250 milliliter flask. One hundred fifty milliliters of toluene was then added. The reaction was allowed to proceed overnight at 110° C., and the byproduct water (˜9 grams) was continuously removed from the reaction by azeotropic distillation. The final solution was evaporated to remove toluene under vacuum, and a yellowish resinous product (˜55 grams) of salicylamide/sorbitol borate was obtained.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06585816B1uspto-grants-2003_07