Reaktion #1441069

Reaktionsgleichung

methyl 2-(2-oxopyrrolidinyl)acetate

hydrazine

→

N-Amino-2-(2-oxopyrrolidinyl)acetamide

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe solution was heated
2. 2
   Temperaturto reflux temperature overnight
3. 3
   SonstigeThe solvent was then removed under reduced pressure
4. 4
   Sonstigethe product was isolated as a solid in a quantitative yield
5. 5
   Sonstigewas used without further purification

Vorschrift

To a solution of methyl 2-(2-oxopyrrolidinyl)acetate (0.884 mL, 6.36 mmol) in 1 mL of anhydrous ethanol was added anhydrous hydrazine (0.308 mL, 6.36 mmol). The solution was heated to reflux temperature overnight. The solvent was then removed under reduced pressure and the product was isolated as a solid in a quantitative yield and was used without further purification: 1H NMR (CDCl3) δ 8.17 (br s, 1H), 3.94 (s, 2H), 3.55 (t, 2H), 2.43 (t, 2H), 2.10 (quintet, 2H); ES-MS (m/z) 158 [M+H]+.

Quelle