Reaktion #1440239

Reaktionsgleichung

Hydralazine

hydrochloric acid

→

hydralazine hydrochloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe solution was filtered hot
2. 2
   Sonstigeto remove traces of insoluble materials that
3. 3
   workup.ADDITIONEthanol (6 to 7 parts by volume) was added to the filtrate

Vorschrift

Hydralazine free base (1 part by weight) was heated in 6 to 7 parts by volume of 15% hydrochloric acid to a temperature of 70–80° C. The solution was filtered hot to remove traces of insoluble materials that were undesired by-products of the preceding step. Ethanol (6 to 7 parts by volume) was added to the filtrate. As the resulting solution cooled to ambient temperature and then further to 3–8° C., an off-white to pale yellow precipitate of the desired product, hydralazine hydrochloride, was obtained. Typical yields were 80–90%.

Quelle