Reaktion #1438891

ord-14c3ed77a3d04228ab4610792aa14900

Reaktionsgleichung

COC(=O)c1ccc2cc(C#N)ccc2c1
6-cyano-naphthalene-2-carboxylic acid methyl ester
O=[N+]([O-])[O-].[K+]
KNO3
→
COC(=O)c1cc([N+](=O)[O-])c2cc(C#N)ccc2c1
6-cyano-4-nitro-naphthalene-2-carboxylic acid methyl ester

Edukte

COC(=O)c1ccc2cc(C#N)ccc2c1
6-cyano-naphthalene-2-carboxylic acid methyl ester
O=[N+]([O-])[O-].[K+]
KNO3

Reagenzien

Keine

Lösungsmittel

O=S(=O)(O)O
sulfuric acid

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    workup.ADDITIONThe reaction mixture is poured into ice
  2. 2
    Filtrationfiltered
  3. 3
    Waschenthe compound is washed with water
  4. 4
    Sonstigedried

Vorschrift

Nitration of 6-cyano-naphthalene-2-carboxylic acid methyl ester, prepared as described in U.S. Pat. No. 6,284,796, is carried out with KNO3 in sulfuric acid at 0° C. for 30 min. The reaction mixture is poured into ice and filtered, and the compound is washed with water and dried. The product, 6-cyano-4-nitro-naphthalene-2-carboxylic acid methyl ester is obtained and used without further purification.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07217794B2uspto-grants-2007_05