Reaktion #1438650

Reaktionsgleichung

4-chloro 6-methyl quinazolone

m-trifluoromethylaniline

→

8-methyl 4 chloro quinazoline

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   ExtraktionTreatment with aqueous Na2CO3 and extraction with CH2Cl2
2. 2
   Sonstigegave 0.2 g of P15 as a white solid, mp—215° C.

Vorschrift

0.45 g of 4-chloro 6-methyl quinazolone and 0.405 g, of m-trifluoromethylaniline in 20 ml ethanol were refluxed 1-hour. Treatment with aqueous Na2CO3 and extraction with CH2Cl2 gave 0.2 g of P15 as a white solid, mp—215° C., as the free base. NMR CDCl3 δ 8.78(1H, S), 8.06(2H, m), 7.86(1H, d, J=7.6 Hz), 7.65(2H, m), 7.54(1H, t, J=8.0 Hz), 7.42(1H, m), 2.58(3H, S).

Quelle