Reaktion #1437617

Reaktionsgleichung

(S)-1,4-dibenzyl-2-(2-furan-3-yl-ethyl)-piperazine

ammonium formate

→

title compound

Ausbeute 43.2%

(S)-2-(2-Furan-3-yl-ethyl)-piperazine

Ausbeute 43.2%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationfilter the palladium
2. 2
   Einengenconcentrate the filtrate
3. 3
   SonstigePurify by silica gel chromatography

Vorschrift

Dissolve (S)-1,4-dibenzyl-2-(2-furan-3-yl-ethyl)-piperazine (810 mg, 2.25 mmol) in ethanol (5 mL). Add ammonium formate (850 mg, 13.5 mmol) and palladium (100 mg, 5 wt. % on carbon) and heat to reflux. After 3.5 h, filter the palladium and concentrate the filtrate. Purify by silica gel chromatography using 7N ammonia in methanol-methylene chloride (5%) as the eluent to give 175 mg (43%) of the title compound: mass spectrum (ion spray): m/z=181 (M+1). Analysis calculated for C10H16N2O: C, 66.63; H, 8.95; N, 11.54. Found: C, 66.53; H, 8.92; N, 11.14.

Quelle