Reaktion #1436629

Reaktionsgleichung

(+)-B-chlorodiisopinocampheylborane

2′methoxyacetophenone

→

title compound

Ausbeute 75.2%

(R)-1-(2-Methoxyphenyl)ethanol

Ausbeute 75.2%

Lösungsmittel

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   Einengenconcentrated under reduced pressure
2. 2
   workup.ADDITIONTo the residue were added diethyl ether (100 ml) and diethanolamine (18.1 g)
3. 3
   workup.STIRRINGthe reaction mixture was stirred at room temperature for 2 hr
4. 4
   FiltrationThe precipitated solid was filtered off
5. 5
   EinengenThe filtrate was concentrated under reduced pressure
6. 6
   workup.DISTILLATIONpurified by distillation under reduced pressure (bp 74–77° C./1 mmHg)

Vorschrift

To a solution of (+)-B-chlorodiisopinocampheylborane (10.5 g) in tetrahydrofuran (50 ml) was added dropwise 2′methoxyacetophenone (10.5 g) at −25° C. The mixture was stirred at −25° C. for 1 hr and concentrated under reduced pressure. To the residue were added diethyl ether (100 ml) and diethanolamine (18.1 g) and the reaction mixture was stirred at room temperature for 2 hr. The precipitated solid was filtered off. The filtrate was concentrated under reduced pressure and purified by distillation under reduced pressure (bp 74–77° C./1 mmHg) to give the title compound (8.00 g).

Quelle