Reaktion #1435798

ord-27e0ff2cf36247ca8d861248998c7c69

Reaktionsgleichung

C[C@@H](O)[C@H](NC(=O)OC(C)(C)C)C(=O)O
(2S,3R)-2-tert-butoxycarbonylamino-3-hydroxy-butyric acid
O=[N+]([O-])c1cc(C(F)(F)F)ccc1F
1-fluoro-2-nitro-4-trifluoromethyl-benzene
→
C[C@@H](Oc1ccc(C(F)(F)F)cc1[N+](=O)[O-])[C@H](NC(=O)OC(C)(C)C)C(=O)O
title compound
C[C@@H](Oc1ccc(C(F)(F)F)cc1[N+](=O)[O-])[C@H](NC(=O)OC(C)(C)C)C(=O)O
(2S,3R)-2-tert-Butoxycarbonylamino-3-(2-nitro-4-trifluoromethyl-phenoxy)-butyric acid

Edukte

C[C@@H](O)[C@H](NC(=O)OC(C)(C)C)C(=O)O
(2S,3R)-2-tert-butoxycarbonylamino-3-hydroxy-butyric acid
O=[N+]([O-])c1cc(C(F)(F)F)ccc1F
1-fluoro-2-nitro-4-trifluoromethyl-benzene

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

In analogous manner to that described in example 5a), the reaction of (2S,3R)-2-tert-butoxycarbonylamino-3-hydroxy-butyric acid and 1-fluoro-2-nitro-4-trifluoromethyl-benzene yielded quantitatively the title compound as a brown oil, MS m/e (%): 426.4(M+NH4+, 85).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07211573B2uspto-grants-2007_05