Reaktion #1435778

ord-91413881f47f46178ad33251be74195a

Reaktionsgleichung

C[C@@H](O)[C@H](NC(=O)OC(C)(C)C)C(=O)O
(2S,3R)-2-tert-butoxycarbonylamino-3-hydroxy-butyric acid
O=[N+]([O-])c1c(F)cccc1F
2,6-difluoro-nitrobenzene
→
C[C@@H](Oc1cccc(F)c1[N+](=O)[O-])[C@H](NC(=O)OC(C)(C)C)C(=O)O
title compound
C[C@@H](Oc1cccc(F)c1[N+](=O)[O-])[C@H](NC(=O)OC(C)(C)C)C(=O)O
(2S,3R)-2-tert-Butoxycarbonylamino-3-(3-fluoro-2-nitro-phenoxy)-butyric acid

Edukte

C[C@@H](O)[C@H](NC(=O)OC(C)(C)C)C(=O)O
(2S,3R)-2-tert-butoxycarbonylamino-3-hydroxy-butyric acid
O=[N+]([O-])c1c(F)cccc1F
2,6-difluoro-nitrobenzene

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

In analogous manner to that described in example 5a), the reaction of (2S,3R)-2-tert-butoxycarbonylamino-3-hydroxy-butyric acid and 2,6-difluoro-nitrobenzene yielded (78% of theory) the title compound as a brown oil, MS m/e (%): 357.3 (M−H+, 100).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07211573B2uspto-grants-2007_05