Reaktion #1435746

Reaktionsgleichung

Dimethyl-[1-(4-nitro-phenyl)-piperidin-4-yl]-amine

thiocarbonyl diimidazole

water

→

[1-(4-Isothiocyanato-phenyl)-piperidin-4-yl]-dimethyl-amine

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionextracted with diethyl ether
2. 2
   TrocknenThe extract was dried with sodium sulfate
3. 3
   Einengenconcentrated
4. 4
   Sonstigeto give a pale yellow solid

Vorschrift

Dimethyl-[1-(4-nitro-phenyl)-piperidin-4-yl]-amine (Example 2, 1.1 g, 5.0 mmol) was dissolved in DMF (5 mL). To the stirred solution, thiocarbonyl diimidazole (Aldrich, 1.18 g, 90%, 6 mmol) was added and the solution was stirred at room temperature for 80 minutes. The mixture was poured into water and extracted with diethyl ether. The extract was dried with sodium sulfate and concentrated to give a pale yellow solid. 1.12 g, 85%. MS (m+H)+: 262.

Quelle