Reaktion #1435726

Reaktionsgleichung

ammonium chloride

5,7-dichloro-6-(2,4,6-trifluorophenyl)imidazo[1,2-a]pyrimidine

4-methylpiperidine

→

5-(4-methylpiperidin-1-yl)-6-(2,4,6-trifluorophenyl)-7-chloroimidazo[1,2-a]pyrimidine

Ausbeute 80.9%

Lösungsmittel

chloroform

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturUnder ice-cooling
2. 2
   WaschenThe separated organic layer was washed with water
3. 3
   Trocknendried over sodium sulfate
4. 4
   Einengenconcentrated
5. 5
   WaschenThe residue was washed with t-butyl methyl ether

Vorschrift

Under ice-cooling, 0.64 g of 5,7-dichloro-6-(2,4,6-trifluorophenyl)imidazo[1,2-a]pyrimidine and 0.79 g of 4-methylpiperidine were mixed. The mixture was allowed to stand at room temperature for one hour, and chloroform and aqueous saturated ammonium chloride solution were added to the reaction mixture. The separated organic layer was washed with water, dried over sodium sulfate and concentrated. The residue was washed with t-butyl methyl ether to give 0.62 g of 5-(4-methylpiperidin-1-yl)-6-(2,4,6-trifluorophenyl)-7-chloroimidazo[1,2-a]pyrimidine

Quelle