Reaktion #1435725

Reaktionsgleichung

diethyl (2,4,6-trifluorophenyl)malonate

2-aminoimidazole hydrochloride

DBU

N,N-dimethylformamide

→

5,7-dihydroxy-6-(2,4,6-trifluorophenyl)imidazo[1,2-a]pyrimidine

Ausbeute 78.3%

Lösungsmittel

water

chloroform

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturto cool to room temperature
2. 2
   EinengenThe separated water layer was concentrated
3. 3
   workup.ADDITIONthe residue was diluted with water and conc. hydrochloric acid
4. 4
   workup.ADDITIONwas added
5. 5
   Temperaturunder ice-cooling
6. 6
   SonstigeThe precipitation
7. 7
   Filtrationwas filtered
8. 8
   Sonstigedried

Vorschrift

A mixture of 2.90 g of diethyl (2,4,6-trifluorophenyl)malonate, 2.39 g of 2-aminoimidazole hydrochloride, 4.57 g of DBU and 10 ml of N,N-dimethylformamide was heated at 100° C. for 6 hours. After allowing the reaction mixture to cool to room temperature, chloroform and water were added thereto. The separated water layer was concentrated, the residue was diluted with water and conc. hydrochloric acid was added thereto under ice-cooling. The precipitation was filtered and dried to give 2.2 g of 5,7-dihydroxy-6-(2,4,6-trifluorophenyl)imidazo[1,2-a]pyrimidine.

Quelle