Reaktion #1414

Reaktionsgleichung

triethylamine

benzylchloroformate

(S)-1,3,4,5-tetrahydro-4-phthalimido-3-oxo-2H-2-benzazepine-2-acetic acid, ethyl ester

ethanol

→

(S)-1,3,4,5-Tetrahydro-4-[[(phenylmethoxy)carbonyl]amino]-3-oxo-2H-2-benzazepine-2-acetic acid, ethyl ester

Lösungsmittel

ethyl acetate

ethyl acetate

toluene

hydrazine hydrate

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationfiltered
2. 2
   Sonstigefiltrate evaporated to dryness
3. 3
   Sonstigeagain evaporated to dryness
4. 4
   Sonstigeplaced in an ice bath
5. 5
   Sonstigethe mixture was partitioned between ethyl acetate-5% potassium bisulfate
6. 6
   WaschenThe organic phase was washed successively with 5% potassium bisulfate, saturated sodium bicarbonate and saturated sodium chloride solutions
7. 7
   Trocknendried (sodium sulfate)
8. 8
   Sonstigeevaporated to dryness
9. 9
   SonstigePurification of the crude product by flash chromatography on silica gel (Whatmann LPS-1)
10. 10
    Wascheneluting with ethyl acetate:hexane (1:2)
11. 11
    Sonstigegave 1.0747 g
12. 12
    SonstigeA sample crystallized from hexane
13. 13
    Sonstige[α]D =+87.2° (c=0.53, chloroform)

Vorschrift

A solution of (S)-1,3,4,5-tetrahydro-4-phthalimido-3-oxo-2H-2-benzazepine-2-acetic acid, ethyl ester (1.67 g., 4.26 mmol.) in 1.0M hydrazine hydrate in ethanol (9.0 ml., 9.0 mmol.) was stirred at room temperature under argon for 36 hours. The mixture was diluted with an equal volume of ethyl acetate, filtered and filtrate evaporated to dryness. The residue was taken up in toluene and again evaporated to dryness. The colorless, semi-solid residue (1.81 g.) was taken up in dry methylene chloride (20 ml.), placed in an ice bath and treated successively with triethylamine (0.80 ml., 5.8 mmol.) and benzylchloroformate (0.77 ml., 5.4 mmol.). After stirring at 0° C. for 2 hours, the mixture was partitioned between ethyl acetate-5% potassium bisulfate. The organic phase was washed successively with 5% potassium bisulfate, saturated sodium bicarbonate and saturated sodium chloride solutions, dried (sodium sulfate), and evaporated to dryness. Purification of the crude product by flash chromatography on silica gel (Whatmann LPS-1) eluting with ethyl acetate:hexane (1:2) gave 1.0747 g. of product as a colorless foam; Rf =0.52 (ethyl acetate:toluene, 3:7). A sample crystallized from hexane had m.p. 80°-82° C.; [α]D =+87.2° (c=0.53, chloroform).

Quelle