Reaktion #1412

ord-e8dac3a3e84b49d4bd31f050b2729740

Reaktionsgleichung

CS[C@@H]1CNC[C@H]1N
trans-3-amino-4-methylthio-pyrrolidine
CC(C)(C)C=O
pivalaldehyde
→
CS[C@@H]1CNC[C@H]1N=CC(C)(C)C
trans-3-(2,2-Dimethyl-propylideneamino)-4-methylthio-pyrrolidine

Edukte

CS[C@@H]1CNC[C@H]1N
trans-3-amino-4-methylthio-pyrrolidine
CC(C)(C)C=O
pivalaldehyde

Reagenzien

Keine

Lösungsmittel

CO
methanol

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    workup.ADDITIONare added dropwise
  2. 2
    Sonstigerises from 25° to 36° C
  3. 3
    Temperaturwithout cooling
  4. 4
    Einengenthe batch is then concentrated
  5. 5
    workup.DISTILLATIONthe residue is distilled

Vorschrift

1.32 g (10 mmol) of trans-3-amino-4-methylthio-pyrrolidine are initially introduced into 5 ml of methanol, and 1.23 ml (11 mmol) of 97% strength pivalaldehyde are added dropwise, after which the temperature rises from 25° to 36° C. The mixture is subsequently stirred for a further 30 minutes, without cooling, the batch is then concentrated and the residue is distilled. Yield: 1.50 g (75% of theory),

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05723627uspto-grants-1998_03