Reaktion #1410

Reaktionsgleichung

3-aminomethyl-pyrrolidine

pivalaldehyde

→

3-[(2,2-Dimethylpropylideneamino)-methyl]-pyrrolidine

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONare added dropwise at room temperature
2. 2
   Sonstigerises to 30° C
3. 3
   Einengenconcentrated
4. 4
   workup.DISTILLATIONthe residue is distilled through a Vigreux column

Vorschrift

2.0 g (20 mmol) of 3-aminomethyl-pyrrolidine are initially introduced into 10 ml of methanol, and 1.8 g (22 mmol) of 97% strength pivalaldehyde are added dropwise at room temperature, after which the internal temperature rises to 30° C. The mixture is subsequently stirred for 1 hour and then concentrated, and the residue is distilled through a Vigreux column.

Quelle