Reaktion #1400

ord-dcc5f15a2f3f46578b2a4b1538a1f0d4

Reaktionsgleichung

Fc1ccc(Cc2ccc(F)cc2)cc1
4,4'-difluorodiphenylmethane
O=S(=O)(O)O
sulfuric acid
→
O=C(c1ccc(F)cc1)c1ccc(F)cc1
4,4'-difluorobenzophenone
Ausbeute 54.0%

Edukte

Fc1ccc(Cc2ccc(F)cc2)cc1
4,4'-difluorodiphenylmethane
O=S(=O)(O)O
sulfuric acid

Reagenzien

[O]=[Mn]=[O]
MnO2

Lösungsmittel

O
water

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    workup.ADDITIONare first mixed
  2. 2
    workup.ADDITIONis added

Vorschrift

The procedure of Example 2 is used except that the 4,4'-difluorodiphenylmethane, water, and sulfuric acid are first mixed, then heated before the MnO2 is added. The yield is 54% 4,4'-difluorobenzophenone that is 95% pure.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05723676uspto-grants-1998_03