Reaktion #1384124

Reaktionsgleichung

2-Bromo-4-chloro-5-fluoro-phenol

Caesium Carbonate

Benzyl bromide

→

1-benzyloxy-2-bromo-4-chloro-5-fluoro-benzene

Lösungsmittel

DMF

brine

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGall was stirred at room temperature for 3 hours under nitrogen
2. 2
   Extraktionextracted into diethyl ether
3. 3
   WaschenThe organic phase was washed several time with brine
4. 4
   Trocknendried over MgSO4
5. 5
   Filtrationfiltered
6. 6
   Einengenconcentrated in vacuo

Vorschrift

2-Bromo-4-chloro-5-fluoro-phenol (1 eq) was taken up in DMF. Caesium Carbonate (2.5 eq) was added and the solution was stirred for 5 minutes. Benzyl bromide (1.05 eq) was added and all was stirred at room temperature for 3 hours under nitrogen. The reaction mixture was diluted with brine and extracted into diethyl ether. The organic phase was washed several time with brine, dried over MgSO4, filtered and concentrated in vacuo, to give 1-benzyloxy-2-bromo-4-chloro-5-fluoro-benzene as an oil, which solidified on standing.

Quelle