Reaktion #1382

Reaktionsgleichung

methyl 2-methyl-3-fluoro-4,6-dibromobenzoate

ethanol

sodium hydroxide

→

2-methyl-3-fluoro-4,6-dibromobenzoic acid

Ausbeute 84.4%

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthe mixture is refluxed for 2 hours
2. 2
   TemperaturAfter cooling
3. 3
   Extraktionextracted with diethyl ether
4. 4
   Extraktionextracted with diethyl ether
5. 5
   EinengenThe solvent is concentrated

Vorschrift

To methyl 2-methyl-3-fluoro-4,6-dibromobenzoate (75.5 g) are added ethanol (460 ml) and 10% aqueous solution of sodium hydroxide (460 ml) and the mixture is refluxed for 2 hours. After cooling, the reaction mixture is diluted with water and extracted with diethyl ether. The aqueous layer is made acidic with conc. hydrochloric acid and extracted with diethyl ether. The solvent is concentrated to give 2-methyl-3-fluoro-4,6-dibromobenzoic acid (61 g), m.p. 144°-146° C.

Quelle