Reaktion #1381

Reaktionsgleichung

Methyl 2-methyl-3-nitrobenzoate

→

methyl 2-methyl-3-aminobenzoate

Ausbeute 101.6%

Lösungsmittel

acetic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeat room temperature
2. 2
   Filtrationthe catalyst is filtered off
3. 3
   EinengenThe reaction mixture is concentrated
4. 4
   workup.ADDITIONis added water
5. 5
   Extraktionfollowed by extraction with dichloromethane
6. 6
   EinengenThe solvent is concentrated

Vorschrift

Methyl 2-methyl-3-nitrobenzoate (10.0 g) is dissolved in acetic acid (50 ml) and thereto 5% Pd-C (1 g) is added to carry out catalytic reduction at room temperature under 1 atm. After 1.5 hours, the catalyst is filtered off. The reaction mixture is concentrated, and thereto is added water, and the mixture is made alkaline with potassium carbonate, followed by extraction with dichloromethane. The solvent is concentrated to give methyl 2-methyl-3-aminobenzoate (8.6 g).

Quelle