Reaktion #1375752

Reaktionsgleichung

2-chloromethyl-6-methylnaphthalene

sodium carbonate

2-pyridylpiperazine

→

1-(6-methyl-β-naphthylmethyl)-4-(2-pyridyl)piperazine

Lösungsmittel

dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONA mixture of 11.0 g
2. 2
   TemperaturThe reaction mixture is cooled
3. 3
   Filtrationfiltered
4. 4
   Einengenthe filtrate is concentrated
5. 5
   WaschenThe precipitate is then washed with water
6. 6
   Sonstigecrystallized from ethanol

Vorschrift

A mixture of 11.0 g. of 2-chloromethyl-6-methylnaphthalene, 7.0 g. of sodium carbonate and 10.0 g. of 2-pyridylpiperazine in 75 ml. of dimethylformamide is stirred for six hours. The reaction mixture is cooled, filtered and the filtrate is concentrated. The precipitate is then washed with water and crystallized from ethanol to yield 1-(6-methyl-β-naphthylmethyl)-4-(2-pyridyl)piperazine.

Quelle