Reaktion #1375749

Reaktionsgleichung

1-(β-napthylmethyl)piperazine

2-chloro-5-hydroxypyrimidine

sodium bicarbonate

→

1-(β-napthylmethyl)-4-(5-hydroxy-2-pyrimidinyl)piperazine

Lösungsmittel

dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONTo a mixture of 4.50 g
2. 2
   TemperaturThe mixture is cooled
3. 3
   Filtrationfiltered
4. 4
   Einengenthe filtrate concentrated to a small volume in vacuo
5. 5
   workup.ADDITIONThe concentrate is diluted with 100 ml
6. 6
   Waschenof water and the insoluble material is washed with water and hexane

Vorschrift

To a mixture of 4.50 g. of 1-(β-napthylmethyl)piperazine(as prepared in Example 7), 2.5 g. of 2-chloro-5-hydroxypyrimidine in 30 ml. of dimethylformamide is added 2.0 g. of sodium bicarbonate and the mixture is refluxed for six hours. The mixture is cooled and filtered and the filtrate concentrated to a small volume in vacuo. The concentrate is diluted with 100 ml. of water and the insoluble material is washed with water and hexane to yield 1-(β-napthylmethyl)-4-(5-hydroxy-2-pyrimidinyl)piperazine.

Quelle