Reaktion #1375748

Reaktionsgleichung

1-(β-naphthylmethyl)-4-(4-methoxyphenyl)piperazine

hydrogen bromide

→

1-(β-naphthylmethyl)-4-(4-hydroxyphenyl)piperazine

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe solution is then cooled
2. 2
   Filtrationfiltered
3. 3
   SonstigeThe collected precipitate is then recrystallized from isobutyl alcohol

Vorschrift

A solution of 2.0 g. of 1-(β-naphthylmethyl)-4-(4-methoxyphenyl)piperazine as prepared in Example 4 in 100 ml. of hot 48% hydrogen bromide is refluxed for 2 hours. The solution is then cooled and filtered. The collected precipitate is then recrystallized from isobutyl alcohol to yield the dihydrobromide salt of 1-(β-naphthylmethyl)-4-(4-hydroxyphenyl)piperazine having a melting point of 225°-227° C.

Quelle