Reaktion #1375747

Reaktionsgleichung

phenylpiperazine

β-chloromethylnapthalene

sodium carbonate

→

1-(β-napthylmethyl)-4-(phenyl)piperazine

Lösungsmittel

dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONA mixture of 10.0 g
2. 2
   TemperaturThe reaction mixture is then cooled
3. 3
   Filtrationfiltered
4. 4
   EinengenThe filtrate is concentrated
5. 5
   FiltrationThe formed precipitate is filtered off
6. 6
   workup.DISSOLUTIONdissolved in isobutyl alcohol
7. 7
   workup.ADDITIONtreated with ethereal hydrogen chloride

Vorschrift

A mixture of 10.0 g. of β-chloromethylnapthalene, 6.0 g. of sodium carbonate and 9.0 g. of phenylpiperazine in 60 ml. of dimethylformamide is stirred under nitrogen on a steambath for five hours. The reaction mixture is then cooled and filtered. The filtrate is concentrated and stirred with ice water. The formed precipitate is filtered off, dissolved in isobutyl alcohol and treated with ethereal hydrogen chloride to yield the hydrochloride salt of 1-(β-napthylmethyl)-4-(phenyl)piperazine having a melting point of 226°-228° C.

Quelle