Reaktion #1375746

Reaktionsgleichung

β-chloromethylnaphthalene

2-pyridylpiperazine

sodium carbonate

→

1-(β-napthylmethyl)-4-(2-pyridyl)piperazine

Lösungsmittel

dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONA mixture containing 7.0 g
2. 2
   FiltrationThe reaction mixture is filtered
3. 3
   FiltrationThe precipitate was filtered
4. 4
   Sonstigerecrystallized from isobutyl alcohol

Vorschrift

A mixture containing 7.0 g. of β-chloromethylnaphthalene, 6.56 g. of 2-pyridylpiperazine and 4.4 g. of sodium carbonate in 40 ml. of dimethylformamide is stirred on a steambath for 90 minutes. The reaction mixture is filtered and the filtrate stirred with ice water. The precipitate was filtered and recrystallized from isobutyl alcohol to yield 1-(β-napthylmethyl)-4-(2-pyridyl)piperazine having a melting point of 124°-126° C.

Quelle