Reaktion #1375745

Reaktionsgleichung

β-chloromethylnaphthalene

sodium carbonate

pyrimidinylpiperazine

→

1-(β-napthylmethyl)-4-(2-pyrimidinyl)-piperazine

Lösungsmittel

dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONTo a mixture containing 5.0 g
2. 2
   Temperaturheated on a steam bath for approximately two hours
3. 3
   TemperaturThe mixture is then cooled
4. 4
   Filtrationfiltered
5. 5
   Einengenthe filtrate is concentrated to a small volume in vacuo
6. 6
   WaschenThe residue is washed with water
7. 7
   Sonstigecrystallized from ethanol

Vorschrift

To a mixture containing 5.0 g. of β-chloromethylnaphthalene, 3.0 g. of sodium carbonate and 30 ml. of dimethylformamide is added 4.6 g. of pyrimidinylpiperazine. The mixture is stirred and heated on a steam bath for approximately two hours. The mixture is then cooled, filtered and the filtrate is concentrated to a small volume in vacuo. The residue is washed with water and crystallized from ethanol to yield 1-(β-napthylmethyl)-4-(2-pyrimidinyl)-piperazine having a melting point of 109°-110° C.

Quelle