Reaktion #1375337

Reaktionsgleichung

5-(ethoxycarbonyloxy)-1,2,4,5-tetrahydro-11-methyl-3-azepino[4,5-b]quinoline-carboxylic acid ethyl ester

hydrochloric acid

→

1,2,4,5-Tetrahydro-5-hydroxy-11-methyl-3H-azepino[4,5-b]quinoline dihydrochloride

Ausbeute 68.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.DISTILLATIONAfter distilling off the hydrochloric acid
2. 2
   Sonstigethe remaining water was removed by entrainment with benzene
3. 3
   Sonstigethe raw salt was recrystallized from methanol

Vorschrift

1,2,4,5-Tetrahydro-5-hydroxy-11-methyl-3H-azepino[4,5-b]quinoline dihydrochloride was prepared from 5-(ethoxycarbonyloxy)-1,2,4,5-tetrahydro-11-methyl-3-azepino[4,5-b]quinoline-carboxylic acid ethyl ester by hydrolysis with 2 N hydrochloric acid for 36 hours at the boiling point. After distilling off the hydrochloric acid, the remaining water was removed by entrainment with benzene, and the raw salt was recrystallized from methanol.

Quelle