Reaktion #1371

Reaktionsgleichung

diethyl 2-methyl-3,4,6-trifluorobenzoylmalonate

p-toluenesulfonic acid

→

ethyl 2-methyl-3,4,6-trifluorobenzoylacetate

Ausbeute 82.6%

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthe mixture is refluxed for 2.5 hours
2. 2
   TemperaturAfter cooling
3. 3
   Extraktionthe resultant is extracted with diethyl ether
4. 4
   Trocknenthe extract is dried over magnesium sulfate
5. 5
   Einengenconcentrated

Vorschrift

To diethyl 2-methyl-3,4,6-trifluorobenzoylmalonate (5.1 g) are added water (20 ml) and p-toluenesulfonic acid (30 mg) and the mixture is refluxed for 2.5 hours. After cooling, the resultant is extracted with diethyl ether, and the extract is dried over magnesium sulfate and concentrated to give ethyl 2-methyl-3,4,6-trifluorobenzoylacetate (3.3 g).

Quelle