Reaktion #1369363

Reaktionsgleichung

1-Acetyl-4-(6-(dimethylamino)-4-fluoropyrimidin-2-yl)piperazine

dimethylamine ethanol

→

title compound

1-Acetyl-4-(4,6-bis(dimethylamino)pyrimidin-2-yl)piperazine

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenThe reaction mixture was concentrated under reduced pressure and chloroform
2. 2
   workup.ADDITIONwas added to the reside
3. 3
   WaschenThe chloroform solution was washed with brine
4. 4
   Trocknendried over anhydrous sodium sulfate
5. 5
   SonstigeThe solvent was evaporated

Vorschrift

1-Acetyl-4-(6-(dimethylamino)-4-fluoropyrimidin-2-yl)piperazine (1.0 g) was dissolved in 12% dimethylamine-ethanol solution (30 ml) in an autoclave, and the mixture was stirred at 100° C. for 5 hr. The reaction mixture was concentrated under reduced pressure and chloroform was added to the reside. The chloroform solution was washed with brine and dried over anhydrous sodium sulfate. The solvent was evaporated to give the title compound (1.3 g) as a pale-yellow solid.

Quelle