Reaktion #1369317

Reaktionsgleichung

2-(4-(4-(aminomethyl)phenylmethyl)piperazin-1-yl)pyrimidine

propionic chloride

triethylamine

→

title compound

N-(4-((4-(Pyrimidin-2-yl)piperazin-1-yl)methyl)phenylmethyl)propionamide

Lösungsmittel

methylene chloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   WaschenThe reaction mixture was washed with water
2. 2
   Trocknendried over anhydrous sodium sulfate
3. 3
   SonstigeThe solvent was evaporated under reduced pressure
4. 4
   Sonstigeto give a pale-yellow substance (0.8 g)
5. 5
   SonstigeThe obtained pale-yellow substance was crystallized from hexane/ethyl acetate (1:1, 50 ml)

Vorschrift

A solution of 2-(4-(4-(aminomethyl)phenylmethyl)piperazin-1-yl)pyrimidine (0.5 g), propionic chloride (0.18 ml) and triethylamine (0.3 ml) in methylene chloride (20 ml) was stirred at room temperature for 2 hr. The reaction mixture was washed with water and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure to give a pale-yellow substance (0.8 g). The obtained pale-yellow substance was crystallized from hexane/ethyl acetate (1:1, 50 ml) to give the title compound (0.5 g) as pale-yellow crystals.

Quelle