Reaktion #1367581

Reaktionsgleichung

sodium hydroxide

3-chlorophenylhydrazine hydrochloride

acetic acid

ethyl 6-chloro-2-(ethoxycarbonyl)-1-methyl-α-oxo-1H-indole-3-acetate

→

compound

Ausbeute 89.1%

Ethyl 7-chloro-3-(3-chlorophenyl)-5-methyl-4-oxo-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-carboxylate

Ausbeute 89.1%

Lösungsmittel

water

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   ExtraktionExtraction
2. 2
   TrocknenThe organic phase is dried over sodium sulphate
3. 3
   Filtrationfiltered
4. 4
   Einengenconcentrated under reduced pressure
5. 5
   SonstigeAn oil is obtained, to which
6. 6
   Temperaturfor 6 h at reflux
7. 7
   TemperaturThe mixture is cooled
8. 8
   Filtrationan insoluble material is collected by filtration
9. 9
   Waschenwashed with water
10. 10
    Sonstigepurified by chromatography on a silica column (eluant: dichloromethane/ethyl acetate: 98/2)

Vorschrift

7.0 g (39.1 mmol) of 3-chlorophenylhydrazine hydrochloride are dissolved in 50 ml of water and 5 ml of a 35% sodium hydroxide solution. Extraction is carried out with diethyl ether. The organic phase is dried over sodium sulphate, filtered and concentrated under reduced pressure. An oil is obtained, to which are added 100 ml of acetic acid and 4.0 g (12.35 mmol) of ethyl 6-chloro-2-(ethoxycarbonyl)-1-methyl-α-oxo-1H-indole-3-acetate. The reaction mixture is stirred for 30 min at room temperature and then for 6 h at reflux. The mixture is cooled, 100 ml of water are added and an insoluble material is collected by filtration, washed with water and purified by chromatography on a silica column (eluant: dichloromethane/ethyl acetate: 98/2). 4.59 g (11 mmol) of compound are isolated in the form of a white solid.

Quelle