Reaktion #1367

Reaktionsgleichung

2-methylthiomethyl-3,4,6-trifluoroaniline

→

2-methyl-3,4,6-trifluoroaniline

Ausbeute 71.3%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationAfter the catalyst is filtered off
2. 2
   workup.ADDITIONthe filtrate is added with water
3. 3
   Extraktionextracted with dichloromethane
4. 4
   TrocknenThe is dried over magnesium sulfate
5. 5
   Einengenconcentrated

Vorschrift

To 2-methylthiomethyl-3,4,6-trifluoroaniline (22.2 g) are added ethanol (400 ml) and Raney nickel (200 g) and the mixture is stirred at room temperature for 30 minutes. After the catalyst is filtered off, the filtrate is added with water and extracted with dichloromethane. The is dried over magnesium sulfate and concentrated to give 2-methyl-3,4,6-trifluoroaniline (12.3 g).

Quelle